Collagenase Chemonucleolysis vs Percutaneous Transforaminal Endoscopic Discectomy for Lumbar Disc Herniation

  • STATUS
    Recruiting
  • End date
    Dec 16, 2022
  • participants needed
    140
  • sponsor
    Shenzhen People's Hospital
Updated on 3 May 2022

Summary

The outcomes of collagen hydrolysis vs PTED effect for lumbar disc herniation

Description

Lumbar disc herniation (LDH) is a common disease with an incidence of 1%-3%, usually manifested as low back pain radiating to the lower extremities, which seriously affects patients' quality of life. Collagen hydrolysis was effective in treating LDH, it makes the protrusion smaller or disappeared, relieving or resolving the compression of nerve root by the protrusion.Percutaneous transforaminal endoscopic discectomy (PTED) is a less invasive techniques to treat LDH. However, the outcomes of collagen hydrolysis vs PTED effect was still unknown.

Details
Condition Lumbar Disc Herniation
Treatment Collagenase, Collagenase, PTED
Clinical Study IdentifierNCT05330806
SponsorShenzhen People's Hospital
Last Modified on3 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

at least six weeks of excessive radiating leg pain with no tendency for any clinical improvement despite conservative therapy
have a nerve root compression by a lumbar disc herniation proven by magnetic resonance imaging

Exclusion Criteria

previous surgery at the same or adjacent disc level
isthmic or degenerative spondylolisthesis
pregnancy
severe comorbid medical or psychiatric disorder (American Society of Anesthesiologists' classification >2)
severe caudal or cranial sequestration of disc fragments, defined as sequestration towards more than half of the adjacent vertebra
contraindication for surgery
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