Rapid Blood Culture Identification Panel in Pediatric Patients in Guatemala

  • STATUS
    Recruiting
  • End date
    Oct 3, 2022
  • participants needed
    200
  • sponsor
    University of Colorado, Denver
Updated on 3 May 2022
antibiotics
antimicrobials
blood culture
antimicrobial agent

Summary

The purpose of this study is to assess the clinical impact of a rapid multiplex PCR blood culture identification panel on time to optimal antimicrobial therapy when compared to conventional microbiological culture methods in children hospitalized in a low resource setting in Guatemala City.

Description

A retrospective review of positive blood cultures was performed on pediatric patients at a tertiary hospital in Guatemala City. These will serve as retrospective controls. The prospective portion of this study will implement the BioFire FilmArray blood culture identification panel (BCID2). Laboratory technicians will perform BCID2 simultaneously with standard culture after it flags positive on the automated blood culture system. BCID2 will be performed on those blood culture specimens that become positive during normal laboratory daytime working hours. Those specimens that become positive overnight will not have the BCID2 performed and will serve as concurrent controls. Physicians will be notified of panel results for the BCID2 intervention group and standard culture results per current laboratory protocol. This study will compare time to optimal antimicrobial therapy (primary outcome), as well as secondary outcome measures, between the intervention group and the 2 control groups.

Details
Condition Bacteremia, Sepsis
Treatment Blood culture identification panel
Clinical Study IdentifierNCT05314816
SponsorUniversity of Colorado, Denver
Last Modified on3 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Age <18 years of age
First positive blood culture during the hospitalization

Exclusion Criteria

Non-blood specimens
Repeat positive blood cultures from the same admission
Patients who expire prior to positive culture
Outpatient blood cultures
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