The Role of Acupuncture-induced Exosome in Treating Post-stroke Dementia

  • STATUS
    Recruiting
  • End date
    Jul 31, 2025
  • participants needed
    30
  • sponsor
    China Medical University Hospital
Updated on 3 May 2022

Summary

Stroke is the main cause of disability and the second main cause of dementia. Approximately 21.5% of patients develop dementia within 4 years after stroke. The main clinical manifestation of dementia is memory and cognitive impairment. At present, acetylcholinesterase inhibitors and NMDA glutamate receptor antagonists, were used for dementia treatment, but those drugs have limited efficacy. Exosome is an extracellular vesicle from the endosomal, size range from ~40 to 160 nm (average ~100 nm). It contains many cells including DNA, RNA, fat, and metabolites, as well as cytoplasm and cell surface proteins that play a role in regulating intercellular communication. Some studies believe that exosomes in the circulation are an ideal marker to reflect the pathological progress and recovery of stroke, and play a key role in the reorganization of tissues and the progress of neurodegeneration after stroke. Our previous studies have known that acupuncture can increase the long-term potentiation of hippocampal CA1 in rats with ischemic stroke, and improve learning-memory and neurological function. Therefore, the purpose of this study is to explore the role of acupuncture-induced exosome in the treatment of post-stroke dementia.

Details
Condition Exosome, Post-stroke Dementia, Acupuncture
Treatment Acupuncture
Clinical Study IdentifierNCT05326724
SponsorChina Medical University Hospital
Last Modified on3 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

History of stroke
MMSE score between 16 and 26

Exclusion Criteria

Those with serious diseases, such as heart failure, chronic failure or cancer patients, etc
Intolerance to acupuncture treatment
Allergy to acupuncture needles
Refusal to sign the informed consent form
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