Esketamine on Postpartum Depression in Cesarean Section Women (EKET)

  • days left to enroll
  • participants needed
  • sponsor
    Ailin Luo
Updated on 22 April 2022
depressed mood
cesarean section


This study was to explore the preventive effect of esketamine on postpartum depression in cesarean section, and to evaluate the safety of the drug


Studies have shown that esketamine can treat clinical refractory depression, the drug takes effect quickly, can quickly eliminate the patient's suicide intention, low-dose maintenance treatment is conducive to the stability of the patient's condition, and less adverse reactions, is the current hot spot of antidepressant drug research. Esketamine has been approved by FDA for the treatment of refractory and suicidal depression, but can it effectively prevent and treat postpartum depression? It is not clear. Based on this, this study aims to explore the preventive effect of prophylactic administration of esketamine on postpartum depression in cesarean section, and evaluate the safety of the drug.

Condition Esketamine, Postpartum Depression
Treatment Normal saline, Esketamine
Clinical Study IdentifierNCT04860661
SponsorAilin Luo
Last Modified on22 April 2022


Yes No Not Sure

Inclusion Criteria

Elective cesarean section
-40 years
Singleton pregnancy
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Exclusion Criteria

ASA grade III and above
Intracranial hypertension
Severe heart disease
Hyperthyroidism patients without treatment or insufficient treatment
Liver and kidney dysfunction
Preeclampsia or eclampsia
Mental disorder, mental retardation
Drug abuse and alcoholism
Contraindication of intraspinal anesthesia
The preoperative EPDS score ≥10
Participated in other clinical studies
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