The Effects of Exercise and Probiotics on Dysmenorrhea and Microbiome

  • STATUS
    Recruiting
  • End date
    Jan 19, 2023
  • participants needed
    80
  • sponsor
    National Taipei University of Nursing and Health Sciences
Updated on 1 May 2022
primary dysmenorrhea
Accepts healthy volunteers

Summary

The study try to investigate the possible effects of exercise and probiotics supplementation on dysmenorrhea amelioration from the perspective of microbiome.

Description

In current study, there were two stages designed for current study. The definition of dysmenorrhea population depended on the Visual Analogue Scale (VAS) of McGill Pain Questionnaire (more than 5) and the VAS score less than 2 was considered as non-dysmenorrhea population.

In the first stage, the 20 subjects were recruit for non-dysmenorrhea group (Control group) and other 60 subjects were randomly allocated into three group with original lifestyle, aerobic, and resistant exercise intervention (Dys-Control, Dys-Aerobic, and Dys-resistant groups). The questionnaires (Premenstrual syndrome, the Menstrual Distress, and McGill Pain), body composition, physical fitness, biochemistries, inflammation, hormones and microbiome analysis (feces and tampon) were evaluated and assessed before and after 10-weeks indicated exercise training.

In the second stage, one hundred subjects (20 non-dysmenorrhea and 80 dysmenorrhea populations) will be recruited and the dysmenorrhea will be randomly allocated into Dys-Control, Dys-probiotics, Dys-exercise and Dys-probiotics and exercise groups. The questionnaires (Premenstrual syndrome, the Menstrual Distress, and McGill Pain), body composition, physical fitness, biochemistries, inflammation, hormones and microbiome analysis (feces and tampon) were evaluated and assessed before and after 10-weeks indicated interventions (probiotics and exercise).

Details
Condition Dysmenorrhea, Inflammation, Microbial Substitution
Treatment Aerobic Exercise, Resistant exercise
Clinical Study IdentifierNCT05326217
SponsorNational Taipei University of Nursing and Health Sciences
Last Modified on1 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Primary dysmenorrhea
Visual Analog Score of McGill pain questionnaire (0-2 for non-dysmenorrhea; >5 for dysmenorrhea)

Exclusion Criteria

Pregnancy, menstrual disorders, obesity (BMI>30), smoking, and alcohol or drug addiction
Cardiovascular disease, hypertension, diabetes, asthma, chronic pulmonary obstruction, mental illness
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