A Trial of a Hospital Policy of Tranexamic Acid Use to Reduce Transfusion in Major Non-cardiac Surgery (TRACTION)
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- STATUS
- Recruiting
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- days left to enroll
- 68
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- participants needed
- 8320
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- sponsor
- University of Manitoba
Summary
A Phase IV trial of a hospital policy of Tranexamic acid to reduce transfusion in major non-cardiac surgery.
Description
The TRACTION Trial is a national multi-centre Phase IV randomized cluster-crossover trial of Tranexamic acid versus placebo. Over the duration of the study, participating centres will be centrally and randomly allocated to receive either TXA or matching placebo at 1-month intervals for a total of 8 months. As our pragmatic trial is designed to define practice, we have selected co-primary outcomes that evaluate effectiveness in the context of safety.
Our co-primary outcomes are the:
- Proportion of patients transfused RBCs
- Incidence of DVT or PE (collectively called venous thromboembolism (VTE) within 3 months of surgery.
Details
| Condition | Major Non-cardiac Surgeries |
|---|---|
| Treatment | Tranexamic Acid (TXA), Placebo (0.9 % Saline) |
| Clinical Study Identifier | NCT04803747 |
| Sponsor | University of Manitoba |
| Last Modified on | 19 April 2022 |
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