Acetaminophen and AKI After Aortic Surgery

  • End date
    Dec 30, 2023
  • participants needed
  • sponsor
    Gangnam Severance Hospital
Updated on 13 April 2022


Acute kidney injury is commonly accompanied major complication after aortic surgery.

Cardipulmonary bypass lyses erythrocyte and induces lipid peroxidation. This increases plasma free hemoglobin, F2-isoprostane, and isofuran concentration. Cell free hemoglobin have been reported to be associated with poor prognosis such as acute kidney injury, myocardial infarction, and death.

Acetaminophen is reported to attenuate hemeprotein mediated lipid peroxidation. Thus, investigators hypothesized that acetaminophen might have protective effect on the incidence of acute kidney injury in patients undergoing aortic surgery with moderate hypothermic circulatory arrest.

Condition Aortic Surgery
Treatment Placebo, Acetaminophen
Clinical Study IdentifierNCT04882202
SponsorGangnam Severance Hospital
Last Modified on13 April 2022


Yes No Not Sure

Inclusion Criteria

Patients undergoing aortic surgery with moderate hypothermic circulatory arrest

Exclusion Criteria

patients with chronic kidney disease or with dialysis, eGFR < 15ml/min/1.73m2
allergy to acetaminophen or propacetamol HCl
history of liver cirrhosis or total bilirubin > 2.0mg/dL
patients taking acetaminophen or diclofenac 4) patients who cannot understand informed consent
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