Effects of Physical Training on Health Markers of Post-bariatric Patients (Obesity)

  • STATUS
    Not Recruiting
  • End date
    Feb 1, 2023
  • participants needed
    160
  • sponsor
    Rio de Janeiro State University
Updated on 27 June 2022
gastric bypass
Accepts healthy volunteers

Summary

The purpose of this clinical trial is to study the effects of resistance training program on physical-functional fitness, muscle mass and strength, endothelial function, blood pressure, biochemical markers of cardiovascular risk and bone metabolism, density and microstructure and quality of life of post-bariatric patients (Study 1). To compare the bone and muscle changes in post-bariatric patients by Roux-en-Y Gastric Bypass Surgery with non-bariatric controls, as well as to correlate these health indicators with surgery time and weight loss (Study 2).

Description

Randomized controlled trial (Study 1) will feature post-bariatric patients in outpatient care at the public health unit. After recruitment, post-bariatric patients will be randomly assigned, with an allocation ratio of 1:1, into two groups: a) Intervention group - that will perform a supervised resistance training program or b) Non-exercised control group - that will receive the standard clinical follow-up. The exercise sessions will include: a) 10-min specific warm-up, consisting of one set of 20 repetitions with loads corresponding to 50% of the resistance used in the first exercise of the training session; b) 45-min of resistance exercises for the upper and lower body (8 single and multi-joint exercises with free weights and machines, including seated rowing, leg press, bench press, leg flexion, pull down, leg extension, shoulder press, and abdominal exercises), performed with 2-3 sets of 8 to 12 repetitions with loads ≥ 70% of one-repetition maximum (1RM) interspersed with 2 min intervals between sets; c) 5-min recovery with stretch and cool-down exercises. During six months, all training sessions will occur three times a week on nonconsecutive days. The outcomes will be assessed by dual energy X-ray emission densitometry (DXA); high resolution peripheral quantitative computed tomography (HR-pQCT), repetition maximum, handgrip strength and cardiopulmonary exercise tests; biochemical analysis (blood lipid profile, blood glucose and biomarkers of bone formation and absorption and calcium metabolism); venous occlusion plethysmography and nailfold videocapillaroscopy; blood pressure measurement; accelerometry; International Physical Activity Questionnaire and 36-Item Short-form Health Survey. The cross-sectional study (Study 2) will have 2 groups: post-bariatric patients group (BG) and control group (CG) - non-bariatric controls. Outcomes will be assessed by DXA; HR-pQCT; handgrip strength and biochemical analysis (blood lipid profile, blood glucose and biomarkers of bone formation and absorption and calcium metabolism).

Details
Condition Obesity, Bariatric Surgery
Treatment Resistance Training
Clinical Study IdentifierNCT04193397
SponsorRio de Janeiro State University
Last Modified on27 June 2022

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