Neuroinflammatory PET Imaging in Autoimmune Encephalomyelitis

  • End date
    Dec 31, 2024
  • participants needed
  • sponsor
    Ruijin Hospital
Updated on 10 April 2022
Accepts healthy volunteers


Autoimmune encephalomyelitis is a heterogeneous group of central nervous system (CNS) autoimmune diseases characterized by the production of anti-neuron-associated autoantibodies which target neuronal surface proteins, synaptic receptors and intracellular antigens. MRI, as a current first-line imaging tool of CNS inflammation, is difficult to diagnose them because the majority of patients have normal MRI images, and only a few may show local signal or structural abnormalities (including inflammation, edema, or atrophy). The 18 kDa translocator protein (TSPO) expression in the CNS is upregulated in response to microglia activation. DPA-714 is high affinity for binding to TSPO, making 18F-labeled DPA-714 (18F-DPA-714) PET a very promising diagnostic imaging tool for neuroinflammation in patients with autoimmune encephalomyelitis.This study aims to explore the value of 18F-DPA-714 PET in the early diagnosis, therapeutic assessment and prognosis in patients with autoimmune encephalomyelitis.

Condition Autoimmune Encephalomyelitis
Treatment 18F-DPA-714 PET
Clinical Study IdentifierNCT05293405
SponsorRuijin Hospital
Last Modified on10 April 2022


Yes No Not Sure

Inclusion Criteria

able to understand the purpose of clinical research and test plan
In the brain and spine cord MR assessment, it is judged as "normal

Exclusion Criteria

Any major mental illness; history of schizophrenia or schizoaffective disorder
Any important neurological disease, such as cerebrovascular disease, inflammation or infectious disease, demyelinating disease, neurodegenerative disease, trauma in brain or spine cord
History of alcohol or drug abuse/dependence
Medical history of cardiac and lung disease, tumors, blood disease, poorly controlled chronic diseases
Patients with pregnancy
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