Community Network-driven COVID-19 Testing and Vaccination of Vulnerable Populations in the Central US (C3)

  • End date
    Dec 10, 2023
  • participants needed
  • sponsor
    University of Chicago
Updated on 10 April 2022
Accepts healthy volunteers


This C3 project, Community network-driven COVID-19 testing of vulnerable populations in the Central US, will implement and evaluate a COVID-19 testing and vaccination approach that combines an evidence-based Social Network Testing Strategy (SNS) with community developed COVID-19 public health messages (SNS+). C3 will engage two disenfranchised populations across rural and urban sites in states across the Central US (Texas (TX), Louisiana (LA), Arkansas (AR), Indiana (IN), Illinois (IL)). C3 leverages NIDA's Justice Community Opioid Innovation Network (JCOIN), the PIs' extensive community located COVID-19 testing programs, and a network of established community partnerships. The collaborative community-academic partnerships, research and engagement infrastructure, and team's leadership across JCOIN will ensure that C3 can rapidly recruit, enroll and test most disenfranchised community members, (n=2400) and through this process, accelerate any forthcoming COVID-19 public health prevention interventions. C3 focuses on two communities most impacted by COVID-19: 1) Criminal justice involved (CJI) - non-incarcerated people with previous history of arrest/jail/prison, probation/parole and drug-court attendance; and 2) Low-income Latinx - community members at 250% or below Federal Poverty Level. Both of these diverse populations, and the overlap between them, have some of the highest rates of COVID-19 infection and death in the United States. Messaging that affirms individual agency and corrects misinformation, combined with accessible and acceptable testing, is required to accelerate COVID-19 prevention for these populations

Condition Covid19
Treatment Social Network Strategy + COVID-19 messaging
Clinical Study IdentifierNCT04743908
SponsorUniversity of Chicago
Last Modified on10 April 2022


Yes No Not Sure

Inclusion Criteria

Index community members will be
18 years or older
spend majority of their time in the metropolitan area or county where recruited
have access to a phone for 21-day follow-up call; and
primary communication in English or Spanish (based on site chart above) AND at least one of the following: (i) CJI in the previous five years (operationalized as any jail, prison, arrest, parole (completed), probation, drug court during this timeframe); (ii) lower-income Latinx (operationalized as at or below 250% of FPL)
Social network referrals will be
linked to the index as a "friend, family, coworker or someone you spend time with on a regular basis
visit within two weeks of index visit
18 years or older
spend the majority of their time in the metropolitan area or county where recruited
have access to a phone for 21-day follow-up call; and
primary communication in English or Spanish

Exclusion Criteria

inability to provide informed consent; and
active COVID-19 symptoms per CDC. Participants with COVID-19 symptoms will be referred for free testing at existing partners for each of the study sites
currently on parole
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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