Camrelizumab Utilization on Patients With Advanced Liver Cancer
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- STATUS
- Recruiting
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- End date
- Jan 13, 2025
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- participants needed
- 1000
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- sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Summary
To observe and evaluate the safety and efficacy of camrelizumab in advanced liver cancer
Description
camrelizumab ， a humanized monoclonal antibody against PD-1, has been shown to block the binding of PD-1 to PD-L1, thereby inhibiting the immune escape of tumor cells. It has a high affinity for PD-1 (KD = 3.31 nmol/L), a high acceptor proportion (85% at 200 mg) of circulating T lymphocytes, and binds to epitopes different from Nivolumab and pembrolizumab，Phase 1 clinical trials have shown that camrelizumab is well tolerated and has antitumor activity in patients with advanced solid tumors.camrelizumab has been approved for indication for advanced hepatocellular carcinoma The main objective of this study was to observe and evaluate the safety and efficacy of treatment regiments containing Camrelizumab in advanced liver cancer。 The subjects included people over 18 years old， For men and women with advanced liver cancer confirmed by histopathology or cytology;
Details
| Condition | Advanced Hepatocellular Carcinoma |
|---|---|
| Treatment | Camrelizumab |
| Clinical Study Identifier | NCT04487704 |
| Sponsor | First Affiliated Hospital Xi'an Jiaotong University |
| Last Modified on | 13 May 2022 |
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