The Arrhythmogenic Potential of Midwall Septal Fibrosis in Dilated Cardiomyopathy (DCM-MSF)

  • STATUS
    Recruiting
  • End date
    Oct 1, 2024
  • participants needed
    120
  • sponsor
    University College, London
Updated on 23 April 2022
ejection fraction
MRI
fibrosis
cardiac mri
dilated cardiomyopathy
Accepts healthy volunteers

Summary

Midwall septal fibrosis (MSF) is a common structural abnormality in non-ischaemic dilated cardiomyopathy (DCM). Its presence is believed to increase the risk of malignant ventricular arrhythmias (VA), but the mechanism of arrhythmogenicity is not known. This is particularly relevant in DCM patients with MSF and mid-range left ventricular ejection fraction (LVEF) as they do not currently fulfil criteria for a primary prevention implantable cardioverter-defibrillator (ICD) insertion.

Access to the epicardium for electrical measurements of the heart can enhance the understanding of arrhythmogenicity in DCM, however direct epicardial access is invasive. Instead, the investigators will non-invasively combine high resolution 256-lead ECG imaging (ECGI) and latest generation cardiovascular magnetic resonance (CMR) to study the hearts of 60 DCM patients with and without MSF regardless of LVEF, and 60 matched healthy volunteers. The investigators recently invented the re-usable and CMR-safe SMART-ECGI vest technology for this purpose. Using supercomputers, the investigators will fuse the collected ECGI/CMR data and run electromechanical simulations of whole-heart activation to non-invasively measure each participant's personalised risk of malignant VA induction.

By panoramically mapping the DCM heart in a single beat, the investigators aim to elucidate how MSF perturbs the cardiac activation front and how this could lead to life-threatening VA. This has the potential to change the method by which cardiologists risk stratify patients with DCM.

Details
Condition Dilated Cardiomyopathy
Treatment Cardiac MRI scan, ECG-Imaging
Clinical Study IdentifierNCT05026112
SponsorUniversity College, London
Last Modified on23 April 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Adults with dilated cardiomyopathy
With and without midwall septal fibrosis on previous CMR

Exclusion Criteria

Needle-phobic patients that would preclude cannulation for contrast injection and blood taking
anyone unwilling to consent
anyone with a conventional contraindication for CMR
anyone with any condition precluding full participation in the study such as DCM patients with infarct-pattern LGE, or subepicardial LGE or non-septal midwall fibrosis (participants with small volume right ventricular insertion point LGE will not be excluded)
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