A Study of the Efficacy and Safety of MK-0616 (Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-008)

    Not Recruiting
  • End date
    Apr 3, 2023
  • participants needed
  • sponsor
    Merck Sharp & Dohme LLC
Updated on 8 August 2022
cardiovascular disease
lipid-lowering therapy
cholesterol level
lipoprotein cholesterol
cholesterol measurement


The purpose of this study is to evaluate the efficacy and safety of MK-0616, an oral PCSK9 inhibitor, in lowering low-density lipoprotein cholesterol (LDL-C) in participants with hypercholesterolemia. The primary hypothesis is that at least one of the four doses of MK-0616 tested in this study is superior to placebo on percent change from baseline in LDL-C at Week 8.

Condition Hypercholesterolemia, Familial Hypercholesterolemia
Treatment Placebo, MK-0616
Clinical Study IdentifierNCT05261126
SponsorMerck Sharp & Dohme LLC
Last Modified on8 August 2022

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