The Significance of Sodium Balance and the Value of Salt-blood Test in Identifying Salt Sensitive Patients (VASA)

  • End date
    Dec 1, 2024
  • participants needed
  • sponsor
    Regional Hospital Holstebro
Updated on 21 April 2022


This is a randomized controlled trial with 72 patients with hypertension examining the effects on blood pressure of sodium restriction and whether the blood analysis Salt-blood test is associated to a decrease in blood pressure. Patients will be randomized 2:1 to either sodium restriction or usual diet for 4 weeks. Baseline measures will be done before intervention and outcome measures after the 4 weeks.

Condition Hypertension,Essential
Treatment Sodium restriction
Clinical Study IdentifierNCT05165823
SponsorRegional Hospital Holstebro
Last Modified on21 April 2022


Yes No Not Sure

Inclusion Criteria

BMI ≤ 35 kg/m2
Essential hypertension
eGFR > 15 ml/min/1,73m2
Albumine-to-creatinine-ratio < 500 mg/g
Safe anticonception if women in childbearing age
Able to adhere to dietary regimen

Exclusion Criteria

Secondary hypertension
Clinically significant heart failure (NYHA 3-4)
Clinically significant liver disease
Diabetes mellitus (type 1 and 2)
Active cancer (except skin cancer)
Renal transplant
Recent stroke, transcient ischemic attack or myocardial infarction (within 6 months)
Proliferative glomerulonephritis or ANCA-related disease
Continuous immunosuppressant treatment
Pregnancy or lactation
Alcohol abuse
If the investigator finds the participant unfit to complete the project
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