CMV IGG Antibodies in Semen as a Predictor for Blood Testis Barrier Damage

  • days left to enroll
  • participants needed
  • sponsor
    Hadassah Medical Organization
Updated on 4 October 2022
Accepts healthy volunteers


To assess whether the presence of Cytomegalovirus (CMV) Immunoglobulin G (IGG) antibodies in semen is a reliable predictor of male subfertility or infertility.


Prospective cohort study performed in the artificial reproductive technology (ART) unit.

The study will evaluate semen and serum samples from the following groups:

  1. Presumably fertile male patients going through ART treatment (for preimplantation genetic testing (PGT) or female indications).
  2. Subfertile/infertile male patients with abnormal semen analysis.
  3. Male patients suffering from unexplained infertility. All samples will be collected on the day of ovum retrieval procedure, and the semen samples will be evaluated only after completing the fertilization process. The samples will be tested for CMV IGG antibodies and testosterone levels in semen and serum. In addition, anti-sperm antibodies will be measured in the serum. The ratio between CMV IGG antibodies in semen and serum will be calculated, and will be compared with presence of hormone profile, semen analysis parameters and ART parameters.

Condition Male Infertility
Treatment Blood test (CMV IGG, Anti sperm antibody, Testosterone levels)
Clinical Study IdentifierNCT05302856
SponsorHadassah Medical Organization
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

All male patients addressing the infertility unit in Hadassah Mt Scopus for IVF procedure

Exclusion Criteria

Refusal to participate
Male partner utilizing pre cycle frozen sperm sample
Donor sperm cycles
Surgically retrieved sperm
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note