Improving Thrombolysis Implementation Based on Electronic Monitoring in Acute Ischemic Stroke (ITEM)

  • End date
    Jun 30, 2023
  • participants needed
  • sponsor
    Second Affiliated Hospital, School of Medicine, Zhejiang University
Updated on 6 April 2022


A cluster randomized controlled trial will be conducted. Hospitals in Zhejiang Province, China, will be randomized into two arms (1:1): an intervention arm and a control arm.

Hospitals in the intervention arm will receive a multilevel intervention based on the AACTT theory, whereas hospitals in the control arm will receive no intervention and maintain routine care. All the hospitals will receive electronic monitoring. Hospitals with no stroke center or with <20 cases received thrombolysis per year will be excluded from the study.

Condition Thrombolysis Rate
Treatment Multilevel intervention
Clinical Study IdentifierNCT05160610
SponsorSecond Affiliated Hospital, School of Medicine, Zhejiang University
Last Modified on6 April 2022


Yes No Not Sure

Inclusion Criteria

Patients presented with clinical signs of acute ischemic stroke within 4.5 hours of stroke onset
Patient's age is >18 years

Exclusion Criteria

Contraindication for intravenous thrombolysis
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