Amyloidosis TTR Flow Reserve Evaluation (AMYTRE)
-
- STATUS
- Recruiting
-
- End date
- Feb 27, 2026
-
- participants needed
- 50
-
- sponsor
- Centre Hospitalier Régional d'Orléans
Summary
Anginal symptoms and signs of ischemia have been reported in some patients with cardiac amyloidosis (TTR) without obstructive epicardial coronary artery disease (CAD).
It was found that coronary microvascular dysfunction was highly prevalent in subjects with cardiac amyloidosis, even in the absence of epicardial CAD. The investigators found lower stress and rest myocardial blood flow (MBF) and lower myocardial flow reserve (MFR) in their cardiac PET (Positron emission tomography) study (13N), including 21 patients.
The advances in SPECT technology including cadmium zinc telluride (CZT) detectors allow to evaluate the MBF and MFR estimation by SPECT as shown in both experimental animal models and also in clinical studies with comparison to PET.
SPECT is more widely available than cardiac PET. Thus, the investigators would like:
- to confirm the results of Dorbala et al using SPECT, and
- to go further with evaluation of the effect of Tafamidis on microvascular dysfunction.
Details
| Condition | Amyloid Cardiomyopathy |
|---|---|
| Treatment | SPECT MPI |
| Clinical Study Identifier | NCT05103943 |
| Sponsor | Centre Hospitalier Régional d'Orléans |
| Last Modified on | 27 June 2022 |
How to participate?
,
You have contacted , on
Your message has been sent to the study team at ,
What happens next?
- You can expect the study team to contact you via email or phone in the next few days.
- Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.
You are contacting
Primary Contact
Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.
Learn moreIf you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
Learn moreComplete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.
Learn moreSimilar trials to consider
Not finding what you're looking for?
Sign up as a volunteer to stay informed
Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.
Sign up as volunteer