Pilot Study of reSET-O to Treatment-as-usual in Acute Care Settings

  • End date
    Mar 1, 2024
  • participants needed
  • sponsor
    Johns Hopkins University
Updated on 18 April 2022


This randomized controlled pilot study will evaluate feasibility, acceptability, and potential efficacy of an app, reSET-O, for patients being started on buprenorphine in acute care settings.


This randomized controlled pilot study will enroll 60 participants, who will be randomly assigned to a treatment as usual (TAU) group or a reSET-O+TAU group after being started on buprenorphine in acute care settings (e.g., emergency department) and referred to community treatment. Study enrollment will last for 3 months after discharge from the acute care setting. Participants in the reSET-O+TAU group will be provided with the reSET-O app and will be encouraged to engage with the app for the 3 months following discharge from the acute care unit. The app works as an extension of cognitive behavioral therapy, providing psychoeducation related to opioid use disorder. All participants will be assessed at study intake and every month during the 3-month intervention.

Condition Opioid-use Disorder
Treatment reSET-O app
Clinical Study IdentifierNCT04817267
SponsorJohns Hopkins University
Last Modified on18 April 2022


Yes No Not Sure

Inclusion Criteria

-65 years old
Opioid use disorder
Eligible for buprenorphine treatment
Has reSET-O compatible mobile device

Exclusion Criteria

Significant psychiatric comorbidity
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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