Noninvasive Brain Stimulation on Memory in Individuals With Mild Cognitive Impairment and History of Brain Injury

  • End date
    Aug 31, 2023
  • participants needed
  • sponsor
    University of Texas Southwestern Medical Center
Updated on 28 April 2022


The study will examine the efficacy of high definition transcranial direct current stimulation (HD-tDCS) and its influence on episodic memory in patients with amnestic mild cognitive impairment and a history of Traumatic brain injury. Ten sessions of HD-tDCS to the dorsal anterior cingulate region is expected to result in improvements in episodic memory measures immediately following the last session and at a 3-month follow-up.


Condition Amnestic Mild Cognitive Impairment, Traumatic Brain Injury, Mild Traumatic Brain Injury
Treatment sham HD-tDCS, High Definition Transcranial Direct Current Stimulation
Clinical Study IdentifierNCT04504630
SponsorUniversity of Texas Southwestern Medical Center
Last Modified on28 April 2022


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Inclusion Criteria

Age 50 and older
Native English speakers
years of education or higher
Active diagnosis of aMCI
History of TBI based on VA/DOD criteria

Exclusion Criteria

TBI within the past 2 years
Lifetime history of stroke, transient ischemic attack, heart attack, or congestive heart failure
Lifetime history of epilepsy
Major psychiatric disorders (i.e., posttraumatic stress disorder, bipolar disorder, schizophrenia)
Substance use disorder
Has metal fragments in head
Taking medications that may interact with the HD-tDCS effect (i.e., amphetamines, L-dopa, carbamazepine, sulpiride, pergolide, lorazepam, dextromethorphan, D-cycloserine, flunarizine, or ropinirole)
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