Phase 1/2 Study of MRTX1719 in Solid Tumors With MTAP Deletion
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- STATUS
- Recruiting
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- End date
- Jan 31, 2024
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- participants needed
- 339
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- sponsor
- Mirati Therapeutics Inc.
Summary
This is a Phase 1/2, open-label, multicenter, study of the safety, tolerability, PK, PD, and anti-tumor activity of MRTX1719 patients with advanced, unresectable or metastatic solid tumor malignancy with homozygous deletion of the MTAP gene.
Description
This first-in-human clinical trial will begin with an exploration of MRTX1719 dose and regimen. As potentially viable regimens are identified, Phase 1b expansion cohorts may be implemented to ensure sufficient safety experience, PK information, and early evidence of clinical activity are available to recommend Phase 2 regimens. In Phase 2, separate cohorts of patients by histological diagnosis and/or baseline characteristics will be evaluated for the clinical activity and efficacy of MRTX1719.
Details
| Condition | Mesothelioma, Non Small Cell Lung Cancer, Malignant Peripheral Nerve Sheath Tumors, Solid Tumor, Pancreatic Adenocarcinoma, Advanced Solid Tumor |
|---|---|
| Treatment | MRTX1719 |
| Clinical Study Identifier | NCT05245500 |
| Sponsor | Mirati Therapeutics Inc. |
| Last Modified on | 4 October 2022 |
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