Serotonin Role on Brain Circuits Involved in Food Avoidance in Anorexia Nervosa (SEVIALANO)

  • End date
    Aug 26, 2023
  • participants needed
  • sponsor
    Centre Hospitalier Universitaire de Saint Etienne
Updated on 26 March 2022
Accepts healthy volunteers


Serotoninergic activity in brain structures involved in food control and avoidance, such as the basal ganglia, is poorly understood in Anorexia Nervosa.


A simultaneous positron emission tomography (PET)- functional magnetic resonance imaging (fMRI) approach and testing of food preferences and choices will provide further insight into the link between potential abnormalities in serotoninergic transmission and the specific food restriction disorder for Anorexia Nervosa. These Data can pave the way for new therapeutic avenues.

Condition Anorexia Nervosa
Treatment Eye tracker, PET imaging using [11C]DASB radioligand.
Clinical Study IdentifierNCT05155280
SponsorCentre Hospitalier Universitaire de Saint Etienne
Last Modified on26 March 2022


Yes No Not Sure

Inclusion Criteria

Signature of written consent
Subject affiliated or entitled to a social security scheme
Inclusion Criteria: Patients with restrictive anorexia nervosa (30 subjects)
Anorexia nervosa common features : fear of weight gain, dysmorphophobia, BMI < 17.5 kg/ m², amenorrhea
Absence of food compulsions and purges
Subgroup 1 (15 subjects) : STAI Y2 anxiety score > 61
Subgroup 2 (15 subjects) : STAI Y2 anxiety score < 51
Inclusion criteria - Female control subjects (15 subjects)
BMI between 18.5 and 25 kg/ m²
Absence of a psychological profile of eating disorder or other psychiatric disorders

Exclusion Criteria

Subjects with an oral contraception and breastfeeding woman
Subject with heart failure
Subject treated during the last three months with neuroleptics, and antiparkinsonian drugs, monoamine oxidase (MAO)-A or monoamine oxidase (MOA)-B inhibitors, tricyclic antidepressants, 5HT reuptake inhibitors, thymo regulators (lithium), antiepileptic dugs, codeine derivatives, morphinics, tramadol-containing products (Topalgic, …),dopaminergic drugs
Subjects with suspected pregnancy; Test β human chorionic gonadotropin (HCG) positive prior to examination
Subjects for whom MRI is contraindicated (pacemaker, intracerebral clips, prosthesis made of ferromagnetic material or claustrophobia)
Subjects unable to sign written consent for participation in the study
Subject deprived of liberty by a judicial or administrative decision
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