Contribution of L-Tyrosine to Human Decision Making in Stressful Situations (TYRO-STRESS)

  • End date
    Nov 25, 2022
  • participants needed
  • sponsor
    Direction Centrale du Service de Santé des Armées
Updated on 25 March 2022
Accepts healthy volunteers


L-tyrosine is a chemical precursor of dopamine. Under specific conditions, tyrosine administration can increase brain dopamine levels and therefore several studies have explored whether tyrosine supplementation can have a beneficial effect on cognitive and behavioural performance that is dependent on dopaminergic function. However, the effects of tyrosine supplementation are mixed: some studies show positive effects while others do not. Stress leads to an increase in dopaminergic activity and turnover in the brain, resulting in a decrease in brain dopamine levels. We propose to study the contribution of tyrosine to decision making and more particularly to the processes of response selection (mediated by the prefrontal cortex and under the influence of the dopaminergic system) in stressful situations.

Condition Stress, Psychological
Treatment Placebo, Blood Collection, cognitive tasks, Electroencephalography (EEG), Electromyography (EMG), L-Tyrosine 500 Mg, Stress exposure, Anxiety scale
Clinical Study IdentifierNCT04518254
SponsorDirection Centrale du Service de Santé des Armées
Last Modified on25 March 2022


Yes No Not Sure

Inclusion Criteria

From 18 to 65 years of age

Exclusion Criteria

Tyrosine intake within the previous 15 days
History of neurological or psychiatric disorder
History of nephrological or endocrine disorder or liver failure
Hereditary tyrosinemia
Clear my responses

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