A Phase 1/1b Dose Escalation/Expansion Study of NGM831 as Monotherapy and in Combination With Pembrolizumab in Advanced or Metastatic Solid Tumors

  • STATUS
    Recruiting
  • End date
    Dec 28, 2024
  • participants needed
    79
  • sponsor
    NGM Biopharmaceuticals, Inc
Updated on 28 October 2022
pembrolizumab

Summary

Study of NGM831 as Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumors

Details
Condition Pancreatic Cancer, Breast Cancer, Gastric Cancer, Non-small Cell Lung Cancer, Cervical Cancer, Endocervical Cancer, Squamous Cell Carcinoma of Head and Neck, Bladder Urothelial Cancer, Colorectal Carcinoma, Esophageal Cancer, Ovarian Cancer, Renal Cell Carcinoma, Prostate Cancer, Melanoma, Mesothelioma, Cholangiocarcinoma
Treatment NGM831, NGM831 plus pembrolizumab
Clinical Study IdentifierNCT05215574
SponsorNGM Biopharmaceuticals, Inc
Last Modified on28 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Histologically or cytologically documented locally advanced or metastatic solid tumor malignancy
Progressed or was intolerant to all available therapies known to confer clinical benefit appropriate for their tumor type, and for which the patient was eligible and willing to receive, or refused standard-of-care (SOC) treatments that are perceived to have marginal clinical benefit
Adequate bone marrow, kidney and liver function
Performance status of 0 or 1
Resolved acute effects of any prior therapy to baseline severity or CTCAE Grade 1 except for AEs not constituting a safety risk by Investigator judgement

Exclusion Criteria

•Prior treatment targeting ILT3
Clear my responses

How to participate?

Step 1 Connect with a study center
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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