Caffeine Supplementation, Resistance Training and Blood Antioxidant Status

  • days left to enroll
  • participants needed
  • sponsor
    The Jerzy Kukuczka Academy of Physical Education in Katowice
Updated on 25 March 2022
Accepts healthy volunteers


The purpose of this study is to verify the effect of acute caffeine intake on resistance training volume and blood antioxidant status, in a randomised, double-blind, placebo-controlled crossover trial.


Caffeine is one of the most commonly consumed psychoactive substances in the world. Several previous studies confirmed that caffeine improves several aspects of exercise performance, including resistance training outcomes. Interestingly, caffeine and its catabolic products, theobromine and xanthine, exhibit antioxidant and prooxidant properties. Additionally, resistance training promotes the generation of reactive oxygen species, which are important for the cellular adaptation process.

Hovewer, to the best of our knowledge, there is no information as to how caffeine combined with resistance training affects blood antioxidant status. Therefore, the aim of this study was to examine acute effects of caffeine supplementation on resistance training volume and blood antioxidant status in resistance trained men.

Condition Caffeine
Treatment Placebo Treatment, Caffeine supplementation
Clinical Study IdentifierNCT05230303
SponsorThe Jerzy Kukuczka Academy of Physical Education in Katowice
Last Modified on25 March 2022


Yes No Not Sure

Inclusion Criteria

written consent to participate
medical permission by physician
resistance-trained," defined as having a minimum of two years of resistance training experience
minimum of 2 workout sessions per week in the last 6 months

Exclusion Criteria

neuromuscular or musculoskeletal disorders
current injury
using any medications, dietary supplements or ergogenic aids which could potentially affect the study outcomes
a positive smoking status
potential allergy to caffeine
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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