Biomarker-driven Intermittent Docetaxel Versus Standard-of-care (SOC) Docetaxel in Metastatic Castration-resistant Prostate Cancer (GUIDE)
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- STATUS
- Recruiting
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- End date
- Jun 30, 2026
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- participants needed
- 120
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- sponsor
- Australian and New Zealand Urogenital and Prostate Cancer Trials Group
Summary
The purpose of this study is to see if a prostate cancer marker in the blood (mGSTP1) can be used to guide chemotherapy treatment. Based on the level of this blood marker, some men may be able to have breaks in treatment rather than having chemotherapy continuously which is the current standard of care. This study will tell us if having these treatment breaks guided by mGSTP1 can improve how men feel during treatment while still treating the prostate cancer effectively.
Docetaxel is a chemotherapy drug that is approved to treat prostate cancer and has been used for many years to treat prostate cancer like yours. Your doctor has already discussed this with you and you have both agreed that docetaxel is the best treatment for you to have at this time. You will have already started this chemotherapeutic treatment with docetaxel.
Details
| Condition | Castration Resistant Prostatic Cancer |
|---|---|
| Treatment | Docetaxel intermittent, Docetaxel standard of care |
| Clinical Study Identifier | NCT04918810 |
| Sponsor | Australian and New Zealand Urogenital and Prostate Cancer Trials Group |
| Last Modified on | 25 March 2022 |
Eligibility
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.
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Learn moreComplete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.
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