Substitution of First Phase Insulin Response in Patient With Type 2 Diabetes.
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- STATUS
- Recruiting
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- participants needed
- 20
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- sponsor
- University Hospital, Gentofte, Copenhagen
Summary
The purpose of the project is to shown whether a little dose of a short acting insulin analogue given 3 time daily before the meals compared with placebo could normalise the increase in blood glucose after teh meals in diet treated Type 2 diabetic patients.
Description
Patients with Type 2 diabtes has a defect in the insulinsecretion combined with an increased insulin resistance. At an intravenously glucosestimulation, patients with Type 2 diabtes has a decresed first phase insulin response compared to healty peoples. Because the hyperglycemia after meal, observed i Type 2 diabetics patients, is related to the defect in the first phase insulin response it is our hypothesis that substitution of the first phase insulin response with a little dose of insulin could normalise the blood glucose after the meal. 20 patients with Type 2 diabetes will in a randomised, placebocontrolled, dobble-dummy study be included for three days treatment with Insulin aspart vs placebo. Primary endpoint is bloodglucose fluctuations monitored by a continously glucose monitor.
Details
| Condition | NIDDM |
|---|---|
| Treatment | Insulin Aspart |
| Clinical Study Identifier | NCT00254085 |
| Sponsor | University Hospital, Gentofte, Copenhagen |
| Last Modified on | 7 November 2020 |
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