A Study to EXhibit Percutaneous Coronary Artery Dilatation With Non-Slip Element Balloon (EXPANSE-PTCA)

  • STATUS
    Recruiting
  • days left to enroll
    21
  • participants needed
    200
  • sponsor
    Infraredx
Updated on 19 June 2022

Summary

The objective of this study is to evaluate safety and effectiveness of the Lacrosse NSE ALPHA coronary dilatation catheter during PCI in subjects with stenotic coronary arteries.

Description

The investigation is a prospective, multi-center, single arm clinical study. The study will be conducted in up to 15 investigational sites in the U.S. This study will enroll and treat 200 subjects, including a minimum of 30 subjects with in-stent restenosis (ISR).

The population for this study is subjects with stenotic coronary artery disease who are suitable candidates for PTCA.

After screening for initial inclusion and exclusion criteria, eligible subjects will be asked to participate in the study by signing a consent form. Following consent, subjects will undergo a baseline visit where additional eligibility criteria will be assessed. An angiogram will be completed to assess for angiographic eligibility. If a non-target lesion is identified, it must be treated successfully prior to target lesion treatment. Once treatment of the target lesion(s) has been attempted, the subject will be considered enrolled in the study.

Subjects will be followed through hospital discharge.

Details
Condition Coronary Stenosis, Coronary Artery Stenosis, In-stent Restenosis
Treatment Lacrosse NSE ALPHA coronary dilatation catheter
Clinical Study IdentifierNCT04985773
SponsorInfraredx
Last Modified on19 June 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 18 years or older
Willing to provide written informed consent and written HIPAA authorization prior to initiation of study-related procedures
Agree to not participate in any other clinical study during hospitalization for the index procedure that would interfere with the endpoints of this study
Clinical evidence of ischemic heart disease, stable/unstable angina, or silent ischemia
Acceptable candidate for PCI and emergency coronary artery bypass grafting and is planned for possible PTCA and/or stent placement
Angiographic inclusion criteria
De novo or restenotic lesion(s) in native coronary arteries, including in-stent restenosis
A maximum of two lesions, including at least one target lesion, in single or double vessel coronary artery disease
If two target lesions are defined, then no non-target lesions can be treated
If a single target lesion is defined, then a single non-target lesion may be treated, but if so, it must be located in a different coronary artery from the target lesion
Target lesion(s) must have a reference vessel diameter between 2.0 mm and 4.0 mm by
visual estimation
Target lesion(s) must have a diameter stenosis of (a) ≥70% by visual estimation or (b) >50% by visual estimation and a fractional flow reserve (FFR) of <0.80 or resting full-cycle ratio (RFR) or instantaneous wave-free ratio (iFR) <0.9
Treatment of non-target lesion, if any, must be completed prior to treatment of target lesion; must not, in the opinion of the investigator, impact the conduct or completion of the index procedure; and must be deemed a clinical angiographic success as visually assessed by the investigator
EXLUSION CRITERIA

Exclusion Criteria

Known hypersensitivity or contraindication to aspirin, heparin, bivalirudin, anti-platelet medications, a clopidogrel non-responder, or sensitivity to contrast media that cannot be adequately pre-medicated or replaced with a clinically suitable alternative
Known diagnosis of type I myocardial infarction (resulting from primary reduction of flow from a culprit lesion likely to have a thrombotic component) within 7 days prior to the index procedure
Known pregnancy or is nursing. Women of child-bearing potential should have a documented negative pregnancy test within 7 days prior to index procedure
Planned target lesion treatment with atherectomy (rotational, orbital or laser), cutting balloon, thrombectomy, lithotripsy or an unapproved device during the index procedure
Serum creatinine >2.0 mg/dl within 7 days prior to the index procedure
Cerebrovascular accident within 6 months prior to the index procedure
Active peptic ulcer or active gastrointestinal bleeding within 6 months prior to the index procedure
Left ventricular ejection fraction <30% based on most recent measurement within a year of the index procedure (if LVEF is not available in the medical records, it may be obtained at the time of the index procedure, prior to enrollment)
Target lesion located within a bypass graft (venous or arterial) or graft anastomosis
Previous percutaneous intervention, within 9 months before the study procedure, on lesions in a target vessel (including side branches) that are located within 10 mm from the current target lesion(s)
Target lesion(s) with complete total occlusion defined as the complete obstruction of a native coronary artery, exhibiting TIMI 0 or TIMI 1 flow, with an occlusion duration of at least 3 months
Unstable hemodynamics or shock
Other medical condition which might, in the opinion of the investigator, put the patient at risk or confound the results of the study
Angiographic exclusion criteria
Target lesion(s) longer than 32 mm by visual estimation
Extreme angulation (90º or greater) within 5 mm of the target lesion
Target lesion(s) demonstrating flow limiting dissection (NHLBI Grade C or higher) prior to deployment of the Lacrosse NSE ALPHA
Unprotected left main coronary artery disease (>50% diameter stenosis)
Coronary artery spasm of the target vessel in the absence of a significant stenosis
Target lesion(s) with angiographic presence of probable or definite thrombus
Target lesion(s) involves a bifurcation requiring treatment with more than one stent or pre-dilatation of a side branch >2.0 mm in diameter
Target lesion(s) located in bifurcation beyond stent struts
Target lesion(s) located distal to an implanted stent
Target lesion(s) with stent damage
Non-target lesion that meets any of the following criteria
Located within a bypass graft (venous or arterial)
Located in an unprotected left main coronary artery
A CTO
Involves a bifurcation
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How to participate?

Step 1 Connect with a study center
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  • You can expect the study team to contact you via email or phone in the next few days.
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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