Efficacy of Prolonged GnRH Test in Male Adolescents With Postoperative HH

  • End date
    Dec 31, 2022
  • participants needed
  • sponsor
    Huashan Hospital
Updated on 25 March 2022
luteinizing hormone
stimulation test
klinefelter syndrome
secondary hypogonadism


The Hypogonadotropic Hypogonadism(HH) could be caused by sellar lesions, sellar surgery or sellar radiotherapy. The incidence of HH after sellar surgery was higher in men than in women, and the therapy of HH was insufficient. Gonadotropin-releasing hormone(GnRH) stimulation test is used to evaluate the function of pituitary-gonadal axis. GnRH can be used to diagnose and treat fertility disorders and other endocrine disorders caused by HH. After a single injection of GnRH, the patients with poor response of luteinizing hormone and follicle stimulating hormone need to take extended provocation test, which is conducive to the formulation of the following treatment. GnRH pump can pulse subcutaneous injection of gonadorelin, which can be used as the extended provocation test.

Condition Hypogonadotropic Hypogonadism
Treatment Gonadorelin
Clinical Study IdentifierNCT05184374
SponsorHuashan Hospital
Last Modified on25 March 2022


Yes No Not Sure

Inclusion Criteria

patients with HH after surgery of the saddle area
sufficient therapy of the hypothalamic-pituitary-adrenal(HPA) and hypothalamic-pituitary-thyroid(HPT) axis

Exclusion Criteria

contradictions to gonadorelin
androgen-dependent prostate cancer
on the therapy of human chorionic gonadotropin(HCG) or testosterone
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