carDIo-ttranSSfOrm nucLEar Imaging Study (DISSOLvE)

  • End date
    Dec 30, 2026
  • participants needed
  • sponsor
    Oregon Health and Science University
Updated on 16 March 2022


The investigators will evaluate the change in myocardial uptake of 99m-technetium pyrophosphate (Tc-99m PYP) tracer on serial planar and SPECT imaging in patients enrolled in the CARDIO-TTRansform clinical trial (NCT04136171).


This is a multicenter trial of 80 subjects enrolled in the CARDIO-TTRansform randomized clinical trial (NCT04136171) who will undergo baseline and follow up Tc-99m PYP to assess for the change in myocardial uptake of the tracer.

Condition Amyloidosis, Transthyretin Amyloid Cardiomyopathy
Treatment 99m-technetium pyrophosphate scintigraphy
Clinical Study IdentifierNCT05259072
SponsorOregon Health and Science University
Last Modified on16 March 2022


Yes No Not Sure

Inclusion Criteria

Patients who were screened and eligible to be enrolled or have been already enrolled in the CARDIO-TTRansform randomized clinical trial (NCT04136171) and have a baseline 99m-technetium pyrophosphate planar and SPECT imaging done within 12 months prior to screening for CARDIO-TTRansform
Patients have to meet the inclusion and exclusion criteria of CARDIO-TTRansform trial to be enrolled
Patient willing to consent for the study and undergo the study procedures

Exclusion Criteria

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