Efficacy and Safety of Belimumab in Neuromyelitis Optica Spectrum Disorders
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- STATUS
- Recruiting
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- days left to enroll
- 2
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- participants needed
- 12
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- sponsor
- Tianjin Medical University General Hospital
Summary
Neuromyelitis Optica Spectrum Disorders (NMOSD) is associated with a pathological humoral immune response against the aquaporin-4(AQP-4) water channel. Belimumab (Benlysta ®) is a human immunoglobulin G1λ monoclonal antibody that inhibits B-cell survival and differentiation by neutralizing soluble B lymphocyte stimulator. Belimumab may benefit some patients with NMOSD due to the important role of B cells in the pathogenesis of NMOSD. Clincial trials may be needed to observe its efficacy and safety.
Description
The investigators primarily aim to observe the time to first relapse from initiation of belimumab treatment.
The secondary outcomes are to determine: The safety profile of belimumab in participants with NMO and whether belimumab improves Expanded Disability Status Scale (EDSS), et al.
Details
| Condition | NMO Spectrum Disorder |
|---|---|
| Treatment | belimumab |
| Clinical Study Identifier | NCT05154734 |
| Sponsor | Tianjin Medical University General Hospital |
| Last Modified on | 28 May 2022 |
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