Stress, EEG, ECG, and Chiropractic

  • days left to enroll
  • participants needed
  • sponsor
    Stephanie Sullivan
Updated on 15 March 2022
Accepts healthy volunteers


The Life University Center for Chiropractic Research is conducting a study to better understand the relationship between subjective stress measures and brain patterns during resting state and an auditory oddball task. A secondary aim is to evaluate the impact of a single session of chiropractic care on the resting state and P300 time locked response after a one-week wait period. An additional outcome assessment for this study will be the recording of an electrocardiogram (ECG) of each participant that will be used to analyze their heart rate variability (HRV). Eligible individuals will receive a physical exam to ensure safety during all procedures. They will then sit for a 6-minute resting state EEG and an auditory oddball task. They will complete a series of questionnaires assessing stress. They will receive a chiropractic adjustment using a handheld instrument called an Activator. They will return one week later for a follow-up assessment consisting of the 6-minute resting state EEG, auditory oddball task, and the questionnaires assessing stress.

Condition Stress
Treatment Chiropractic adjustment using an activator
Clinical Study IdentifierNCT05245409
SponsorStephanie Sullivan
Last Modified on15 March 2022


Yes No Not Sure

Inclusion Criteria

Individuals between the ages of 18 and 40
Individuals who can wear an EEG cap for 40 minutes
Individuals who can sit quietly for at least 15 minutes
Individuals who have not had a chiropractic adjustment within the last two weeks
Individuals who have not received any other interventions, such as osteopathic spinal manipulation, physical therapy rehabilitation or manipulation, massage, body movement therapies or acupuncture within the last 2 weeks

Exclusion Criteria

Individuals who have been diagnosed with a serious mental disorder such as schizophrenia or major depressive disorder that could influence EEG results
Individuals who do not feel they can sit quietly with limited movement for roughly 15 minutes
Individuals who are on psychotropic medications (e.g. Benzodiazepine medications) that influence EEG readings (Benzodiazepine medications include but are not limited to: alprazolam, chlordiazepoxide, clobazam, clonazepam, clorazepate, diazepam, estazolam, flurazepam, lorazepam, midazolam, oxazepam, temazepam, triazolam, etc.)
Individuals with any injury or surgery to the skull in the last 6 months, or a history of trauma to the head such as a concussion or stroke
Individuals with a hearing impairment (due to the auditory stimulus recording being performed)
Individuals who are currently pregnant
Individuals with a current litigation related to a physical, health-related injury
Individuals with untreated diagnosed osteoporosis or articular instability, such as atlanto-axial instability
Individuals with a known heart condition that results in an aberrant ECG recording
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