Extension Study of Bomedemstat (IMG-7289) in Patients With Myeloproliferative Neoplasms

  • End date
    Dec 12, 2026
  • participants needed
  • sponsor
    Imago BioSciences,Inc.
Updated on 12 July 2022


This is a multi-center, open-label extension study to assess the long-term safety and efficacy of bomedemstat administered orally once daily in patients with an MPN who participated in a prior bomedemstat study such as, but not limited to, IMG-7289-CTP-102 and IMG-7289-CTP-201 (referred to hereafter as 'feeder studies').

Condition Thrombocythemia, Essential, Primary Myelofibrosis
Treatment Bomedemstat
Clinical Study IdentifierNCT05223920
SponsorImago BioSciences,Inc.
Last Modified on12 July 2022


Yes No Not Sure

Inclusion Criteria

Completed at least one Treatment Period (TP) in a prior bomedemstat MPN protocol (such as, but not limited to, IMG-7289-CTP-102 or IMG-7289-CTP-201)
In the estimation of the Investigator, the risk-benefit favors continued dosing with bomedemstat

Exclusion Criteria

Ongoing participation in another investigational study (except observational studies)
A history of non-compliance in a prior bomedemstat study (excluding dose suspensions that were medically warranted)
Current use of a prohibited medication (e.g., romiplostim)
Medical, psychiatric, cognitive, or other conditions that, in the Investigator's opinion, compromise the patient's safety, ability to give informed consent, or comply with the trial protocol
Females who are pregnant or breastfeeding or plan to become pregnant or breastfeed during the study
Women of childbearing potential (WOCBP) and fertile men unwilling to agree to use an approved method of contraception from time of enrollment until 14 days after last bomedemstat dose
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