Clinical and Biochemical Evaluation of the Efficacy of Non-Surgical Treatment Approaches in the Treatment of Peri-implantitis

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    Hacettepe University
Updated on 14 March 2022
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Peri-implantitis is a pathological condition associated with plaque that develops around dental implants, characterized by inflammation and progressive bone loss in the peri-implant area. Bleeding on probing, suppuration, increased pathological pocket depths and/or mucosal recessions are seen with radiographic bone loss in peri-implantitis. When evaluated histologically, the lesion extends to the apical part of the pocket epithelium and contains a large amount of plasma cells, macrophages and neutrophils. In the Peri-implant crevicular fluid analysis, which is one of the most important parameters that enable the biochemical and immunological evaluation of the inflammatory state in the peri-implant region, information about the current inflammatory situation can be obtained by evaluating the content of an osmotic inflammatory exudate originating from the vessels in the gingival plexus. Many surgical and non-surgical methods have been proposed for the treatment of peri-implantitis. Mechanical surface debridement, laser application and air abrasives are a part of non-surgical treatment of peri-implantitis. In this study, we examined the effectiveness of diode laser in addition to mechanical debridement with titanium curettes. In our study, we aimed to compare these two treatments biochemically by determining the changes in interleukin-1β, Interleukin-10, Interleukin-17, RANKL, osteoprotegerin, TWEAK and sclerostin biomarkers in Peri-implant crevicular fluid and clinically.


Primary outcome measures (probing depth as clinical parameter) and secondary outcome measures ( collection of gingival crevicular fluid, gingival bleeding time index, gingival index, plaque index and clinical attachment level) asre recorded in baseline, third and sixth month. The change between these parameters is observed.

Condition Peri-Implantitis
Treatment diode laser, Titanium curettes
Clinical Study IdentifierNCT05201443
SponsorHacettepe University
Last Modified on14 March 2022


Yes No Not Sure

Inclusion Criteria

Presence of 5mm or more peri-implant pockets
Not having periodontal treatment in the last 3 months
The informed consent form must be approved
At least 18 years old

Exclusion Criteria

Presence of systemic disease
Regular use of non-steroidal anti inflammatory drugs
Having been treated with antibiotics in the last 3 months
Individuals in need of pre-treatment antibiotic prophylaxis
Pregnancy and lactation
Not approving the informed consent form
Patients with known allergies
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