Do Markers of Systemic Inflammatory Response and Tumor Metabolism Indicate Radioresistance in Head and Neck Cancer?

  • STATUS
    Recruiting
  • End date
    Dec 24, 2025
  • participants needed
    100
  • sponsor
    Luzerner Kantonsspital
Updated on 24 March 2022

Summary

The aim of the study is to prospectively evaluate whether markers of a patient's systemic inflammatory response in addition to FDG-PET/CT metabolic parameters of the primary tumor or of nodal metastases can predict radioresistance and survival before primary radiochemotherapy in advanced head and neck cancer patients.

Description

This study prospectively investigates pretherapeutic markers of systemic inflammatory response (including neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, systemic inflammation response index, and systemic immune-inflammation) and FDG-PET/CT-derived metabolic parameters of tumor and nodal metastases (including maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis) and their potential prognostic value in head and neck cancer patients prior to primary radiochemotherapy.

Details
Condition Head and Neck Squamous Cell Carcinoma
Treatment Radiochemotherapy
Clinical Study IdentifierNCT05217212
SponsorLuzerner Kantonsspital
Last Modified on24 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

histopathologic diagnosis of squamous cell carcinoma of the head and neck
primary radio(chemo)therapy with curative intent
available pretherapeutic FDG-PET/CT imaging
available pretherapeutic differential blood analysis

Exclusion Criteria

other tumor entities of the head and neck including cutaneous squamous cell carcinoma
primary surgical treatment
ongoing infections or other inflammatory diseases at the time of diagnosis
patients not completing a course of irradiation with at least 66 Gray locally
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