Safety and Immunogenicity of 2 Doses Versus 1 Dose of Acellular Pertussis Vaccines Containing Genetically-detoxified Pertussis Toxin in Young Adults Previously Primed With Acellular Pertussis Vaccines (Pertagen2x)

  • STATUS
    Recruiting
  • days left to enroll
    2
  • participants needed
    100
  • sponsor
    University Hospital, Geneva
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Updated on 24 March 2022
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vaccination
acellular pertussis vaccine
toxoid
pertussis toxin
Accepts healthy volunteers

Summary

A significant increase of pertussis incidence is reported in a growing number of countries. This resurgence is considered as resulting from the limited durability of aP-vaccine-induced immunity and is associated with increased mortality in young infants and morbidity at all age groups. As the pertussis immunity acquired through immunization or infection is short-lived, its maintenance or reactivation requires repeat boosting at regular time points. Thus, novel strategies capable of reactivating pertussis immunity are needed.

The efficacy of current acellular pertussis vaccines (which contain chemically-detoxified pertussis toxoid (PT)) rapidly wanes, in part because priming and repeat immunization with acellular vaccines induce antibodies specific for the chemically-detoxified PT but unable to efficiently recognize the native PT expressed by B. pertussis.

Clinical studies have shown the superior immunogenicity profile of acellular pertussis vaccines including genetically-detoxified PT (rPT) in adults and adolescents previously primed with aP. In particular, the investigators showed in a past Geneva study in teenagers previously primed with aP that rPT/FHA induced a stronger recall response than the current aP-vaccine at one month post-vaccination. However, the difference was less clear one year after vaccination, suggesting that 2 doses may be needed for more sustained immunity.

In the present study, the investigators would like to assess whether giving two doses of rPT/FHA at 6 months interval induces stronger immune responses than a single dose.

Details
Condition Pertussis, Vaccine-Preventable Diseases
Treatment Pertagen®, Revaxis®
Clinical Study IdentifierNCT05193734
SponsorUniversity Hospital, Geneva
Last Modified on24 March 2022

Eligibility

 Yes No Not Sure

Inclusion Criteria

Has provided written informed consent
Male or female, ages 18 to 30 years (inclusive) at the time of enrollment
With documented history of acellular pertussis immunization (5 doses)
Free of clinically significant health problems, as determined by pertinent medical history and clinical examination at study screening
Non-pregnant, non-lactating females
Able to attend all scheduled visits during one year and to understand and comply with the study procedures

Exclusion Criteria

Prior dTpa immunization within the last 5 years or prior dT immunization within the last 2 years, or any other investigational vaccine likely to impact on interpretation of the trial data
Suspected or confirmed pertussis infection within the last 10 years or documented pertussis infection in a household member within the last 10 years
History of severe local or systemic reactions to any vaccination
Known hypersensitivity or allergy to diphtheria, tetanus, or pertussis-containing vaccines (including excipients)
Receipt of investigational product up to 30 days prior to enrollment or ongoing participation in another interventional clinical trial
Receipt of licensed vaccines within 30 days of planned study immunization or ongoing participation in another clinical interventional trial likely to interfere with study results
Acute or chronic, clinically significant psychiatric, hematologic, pulmonary, cardiovascular, or hepatic or renal functional abnormality as determined by the Investigator based on medical history and physical exam
Any confirmed or suspected immunosuppressive or immunodeficient condition, including human immunodeficiency virus (HIV) infection, asplenia, cytotoxic therapy in the previous 5 years, and/or diabetes
Has a known history of vaccine-induced Guillain-Barré Syndrome
Has an active malignancy or recent (<10 years) history of metastatic or hematologic malignancy
Suspected or known alcohol and/or illicit drug abuse within the past 5 years
Pregnant or lactating female, or female intending to becoming pregnant during the study period
Administration of immunoglobulins within the 120 days preceding study entry or planned administration during the study period
History of blood donation (at least 450 ml) within 30 days of enrollment or plans to donate within the 30 days following and preceding each blood draw
Receipt of chronic (>14 days) immunosuppressants or other immune-modifying drugs within 6 months of study entry
Any other significant finding that, in the opinion of the investigator, would increase the risk of the individual's having an adverse outcome by participating in this study
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