Accelerated Continue Theta-burst Stimulation (acTBS)Treatment for Obsessive Compulsive Disease

  • STATUS
    Recruiting
  • End date
    Dec 1, 2022
  • participants needed
    60
  • sponsor
    Anhui Medical University
Updated on 24 March 2022
transcranial magnetic stimulation

Summary

The therapeutic effects of high-dose accelerated continue theta-burst stimulation (acTBS) and 1-Hz repetitive transcranial magnetic stimulation (rTMS) on obsessive-compulsive disorder (OCD) and its neural mechanism were investigated by functional MRI.

Description

All patients underwent a medical evaluation that included physical examination and routine laboratory studies before and after transcranial magnetic stimulation (rTMS) treatment. Patients were randomly allocated to 1-Hz rTMS group and acTBS group. There are about 30 patients in each group. Patients ware allocated by random number. The decision to enroll a patient was always made prior to randomization. The 1-Hz rTMS group received one round of stimulation every day for 30 minutes with a total stimulation of 1800 pulses for 5 consecutive days. Patients in the acTBS group received 10 two-minute rounds of stimulation each day, spaced 50 minutes apart, with a total of 18,000 pulses for five days.

Before the TMS treatment, Y-BOCS, Obsessions Symptom Scale revised (OCI-R), Hamilton Depression Scale (HAMD-17) and Hamilton Anxiety Scale (HAMA-14) were obtained by a trained investigator to assess baseline severity and other symptoms. The patients had receiving a battery measure of neuropsychological tests (standardized tests to investigate their cognitive problems, anxiety and depressive symptoms in daily life), magnetic resonance imaging scan in multimodalities。

After the last treatment, Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), OCI-R, HAMD-17 and HAMA-14 were obtained, as well as the Global Index of Safety to assess adverse events of the treatment. Patients were instructed to focus their answers on the past 5 days.The patients had also receiving a battery measure of neuropsychological tests and magnetic resonance imaging scan in multimodalities.

Participants were interviewed for two and four weeks after their last treatment to obtain a Y-BOCS score, and they were asked to focus their answers on the past week.

Details
Condition Obsessive-Compulsive Disorder, Accelerated Continue Theta-burst Stimulation, Transcranial Magnetic Stimulation, Functional Magnetic Resonance Imaging
Treatment transcranial magnetic stimulation with real coil
Clinical Study IdentifierNCT05221632
SponsorAnhui Medical University
Last Modified on24 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Clinical diagnosis of obsessive-compulsive disorder
Voluntarily participated and cooperated with the experiment

Exclusion Criteria

History of significant head trauma or neurological disorders
Alcohol or drug abuse
Organic brain defects on T1 or T2 images
History of seizures or unexplained loss of consciousness
Family history of medication refractory epilepsy
Recent aggression or other forms of behavioral dyscontrol
Clear my responses

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