Functional Sucrase Deficiency in Short Bowel Syndrome Patients With Intestinal Failure

  • STATUS
    Recruiting
  • End date
    Jan 1, 2023
  • participants needed
    10
  • sponsor
    University of Miami
Updated on 23 March 2022

Summary

Short gut syndrome with intestinal failure patients may have decreased production of disaccharidases, like sucrase, an enzyme responsible for digesting sugar in foods. This can happen due to loss of bowel length from surgery or from loss of cellular function in the intestines due to use of parenteral nutrition intravenously. Therefore, patients with these conditions may not be able to digest sucrose (sugar) fully. Patients might experience abdominal distension/pain, vomiting and diarrhea when sugar is taken in orally or through the g-tube, which can limit patients' ability to increase oral or g-tube feeds in short gut syndrome patients with intestinal failure.

In patients with short gut syndrome and intestinal failure, the administration of exogenous sucrase (enzyme) may improve sucrose (sugar) digestion and thus the ability to tolerate more oral or g-tube feeds.

Details
Condition Short Gut Syndrome
Treatment Placebo, Sucrase, Sucrase
Clinical Study IdentifierNCT04604275
SponsorUniversity of Miami
Last Modified on23 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Short bowel syndrome, of all ages, with dependence on parental support to provide at least 50% of fluid or caloric needs
Must be on diet containing sucrose
Must be willing and able to sign informed consent
Adult and Pediatric patients (all ages)

Exclusion Criteria

Current IV antibiotic administration for confirmed bout of bacteremia
No enteral nutrition
Any condition, disease, illness, or circumstance that in the investigator's opinion puts the subject at any undue risk, prevents completion of the study, or interferes with analysis of the study results
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