Identification by Transcriptomic Approach of New Prognostic and Predictive Markers in a Cohort of Atypical Meningiomas (TransMenAtyp)

  • End date
    Oct 31, 2023
  • participants needed
  • sponsor
    Central Hospital, Nancy, France
Updated on 13 March 2022


Determine by a transcriptomic approach new prognostic and predictive markers in atypical meningiomas (WHO grade II).

Retrospective observational study, on a cohort of 85 atypical meningiomas. Transcriptomic study first, on cryopreserved tumor samples. Then identify, thanks to the transcriptomic study, prognostic and predictive factors (study of the link between the quantity of certain RNA transcripts and progression-free survival). Finally, set up immunohistochemical applications, which can be used routinely by the pathologist.

Condition Meningioma Atypical
Clinical Study IdentifierNCT05259332
SponsorCentral Hospital, Nancy, France
Last Modified on13 March 2022


Yes No Not Sure

Inclusion Criteria

Primary operated patients for an atypical meningioma (WHO grade II) in the Neurosurgery department of the University Hospital of Nancy
At least one postoperative follow-up visit
Adult patients (>18 yo) at the time of the intervention
Surgical excision

Exclusion Criteria

History of meningioma in the same location
Neo-adjuvant treatment
Absence of non-objection form
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