Study of Pemetrexed+Platinum Chemotherapy With or Without Cosibelimab (CK-301) in First Line Metastatic Non-squamous Non-Small Cell Lung Cancer (CONTERNO)

  • STATUS
    Not Recruiting
  • End date
    May 13, 2025
  • participants needed
    560
  • sponsor
    Checkpoint Therapeutics, Inc.
Updated on 19 August 2022

Summary

This is an efficacy and safety study of cosibelimab (CK-301) combined with pemetrexed/platinum chemotherapy versus pemetrexed/platinum chemotherapy alone in participants with advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) who have not previously received systemic therapy for advanced disease. Participants will be randomly assigned in a 2:1 ratio to receive cosibelimab combined with pemetrexed/platinum (Investigators choice of cisplatin or carboplatin), OR pemetrexed/platinum (Investigators choice of cisplatin or carboplatin).

The primary hypothesis is that cosibelimab in combination with pemetrexed/platinum chemotherapy prolongs Overall Survival (OS) compared to pemetrexed/platinum chemotherapy alone.

Details
Condition Metastatic Non-squamous Non Small Cell Lung Cancer
Treatment cisplatin, carboplatin, Pemetrexed, Dexamethasone 4mg, Vitamin B12 1000 μg, Cosibelimab, Folic acid 350-1000 μg
Clinical Study IdentifierNCT04786964
SponsorCheckpoint Therapeutics, Inc.
Last Modified on19 August 2022

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