Effect of Melatonin on Palatal Wound Healing (Randomized Controlled Clinical Trial)

  • STATUS
    Recruiting
  • days left to enroll
    78
  • participants needed
    26
  • sponsor
    Salma Nabil
Updated on 23 March 2022

Summary

The aim of the study is to assess the effect of topical melatonin loaded gelatin sponge on donor palatal site healing, after palatal graft harvesting.

Description

Autogenous soft tissue grafts can be considered the gold standard treatment for many muco-gingival problems. The most common site for harvesting soft tissue grafts is the palate. Many harvesting techniques have emerged, but the epithelialized graft harvesting technique is one of the most reliable and effective techniques as it imparts the superficial section of the connective tissue which contains the highest amount of lamina propria. Unfortunately, it leaves an open palatal wound healed by secondary intention, increasing pain and post-operative morbidity. In order to overcome these inadequacies investigators will cover the donor site with melatonin loaded gelatin sponge and evaluate its effect on the healing process.

Details
Condition Wound Heal
Treatment Melatonin, Carbopol, Carbopol
Clinical Study IdentifierNCT05122130
SponsorSalma Nabil
Last Modified on23 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients who have at least one site of natural dentition or dental implants that need to be treated by free palatal graft surgery for indications including progressive recession, planned prosthodontics, presence of a mucogingival deformity, or a lack of keratinized gingiva
Patients who have at least 4 mm thickness of palatal mucosa (at donor site)

Exclusion Criteria

History of smoking
Patients who have any known disease that interfere with periodontal surgery
Patients who have any dermal or autoimmune diseases
Patients who have any previous adverse reactions to the products (or similar products) used in this study
Pregnant and lactating women
Patients who have a palatal infection
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