Effect of Melatonin on Palatal Wound Healing (Randomized Controlled Clinical Trial)

  • participants needed
  • sponsor
    Salma Nabil
Updated on 7 February 2023


The aim of the study is to assess the effect of topical melatonin loaded gelatin sponge on donor palatal site healing, after palatal graft harvesting.


Autogenous soft tissue grafts can be considered the gold standard treatment for many muco-gingival problems. The most common site for harvesting soft tissue grafts is the palate. Many harvesting techniques have emerged, but the epithelialized graft harvesting technique is one of the most reliable and effective techniques as it imparts the superficial section of the connective tissue which contains the highest amount of lamina propria. Unfortunately, it leaves an open palatal wound healed by secondary intention, increasing pain and post-operative morbidity. In order to overcome these inadequacies investigators will cover the donor site with melatonin loaded gelatin sponge and evaluate its effect on the healing process.

Condition Wound Heal
Treatment Melatonin, Carbopol, Carbopol
Clinical Study IdentifierNCT05122130
SponsorSalma Nabil
Last Modified on7 February 2023

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