Acute Pancreatitis and Coagulation Study (APK)

  • STATUS
    Recruiting
  • End date
    Jan 1, 2025
  • participants needed
    250
  • sponsor
    Region Skane
Updated on 23 March 2022

Summary

The study aims to investigate pathophysiological changes in coagulation in relation to inflammation in patients with acute pancreatitis. Serum and plasma is sampled repeated days from admission. Analysis will be done after recruitment. Specific biomarkers accuracy for prediction of moderate and severer acute pancreatitis will be calculated.

Description

Inclusion criteria:

Patients with acute pancreatitis admitted to Skåne University Hospital in Malmö

Acute pancreatitis is defined as minimum 2 out of following: amylase levels >3 times upper reference limit, clinical signs of acute pancreatitis, imaging findings of acute pancreatitis)

Exclusion criteria:

<18 years of age

>72 hours from onset of symtom until first sampling

Patients with immunosuppression or autoimmune diseases are excluded from som parts of the study.

Methods: Serum and plasma is sampled repeatedly during the hospital admission. Pre defined protocols are used for data collections of relevant clinical information.

Specific aspects of inflammation, thrombin generation, platelet function and Microparticles will be analysed in serum or plasma during the first consecutive days of acute pancreatitis.

Biomarkers for severe disease as well as correlation between inflammation and coagulopathy will be investigated.

Details
Condition Acute Pancreatitis
Treatment Exploratory for different markers
Clinical Study IdentifierNCT05201053
SponsorRegion Skane
Last Modified on23 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Acute Pancreatitis, accept informed consent -

Exclusion Criteria

More than 72h from onset of symtoms until first sample, patient already
included once
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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