Multimodal GA for Lumbar Spine Surgery

  • STATUS
    Recruiting
  • End date
    Dec 23, 2023
  • participants needed
    160
  • sponsor
    National Taiwan University Hospital
Updated on 23 March 2022

Summary

To evaluate the effects of multimodal general anesthesia on the recovery profile of elder patients undergoing lumbar spine fusion surgery.

Description

Multimodal general anesthesia has been proposed in recent years. By administration of multiple agents acting on a different component of the nociceptive pathways, the multimodal general anesthesia may elicit maximal anesthetic effects with minimal anesthetic dose. These may be beneficial to improve postoperative recovery and reduce adverse effects such as postoperative delirium and perioperative neurocognitive impairment. It is not uncommon that elder patients undergoing lumbar spine fusion surgery suffer from postoperative poor recovery, postoperative delirium as well as the postoperative neurocognitive disorder. Therefore, this study aims to explore the potential effects of multimodal general anesthesia, which comprised with electroencephalography density spectrum array guided co-administration of sevoflurane, ketamine and dexmedetomidine, on the postoperative recovery profiles for elder patients undergoing lumbar spine fusion surgery.

Details
Condition Lumbar Spine Fusion Surgery
Treatment dexmedetomidine, ketamine co-administration with sevoflurane for general anesthesia, Conventional general anesthesia by administration of sevoflurane alone
Clinical Study IdentifierNCT05247177
SponsorNational Taiwan University Hospital
Last Modified on23 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

patients with ages at least 60-year undergoing elective lumbar spine surgery
Exclusion
A history of dementia
Impaired liver function, eg. AST or ALT >100; liver cirrhosis > Child B class
Impaired renal function, cGFR< 60 ml/min/1.73 m2
Cardiac dysfunction, such as heart failure > NYHA class II
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