Study of Combined Decompressive Spine Radiosurgery and Pembrolizumab

  • STATUS
    Recruiting
  • End date
    Sep 30, 2023
  • participants needed
    10
  • sponsor
    Wake Forest University Health Sciences
Updated on 30 May 2022
primary cancer

Summary

The purpose of this research study is to find out what effects (good and bad) Pembrolizumab and radiosurgery have on participants with high-grade epidural disease of the spine.

Description

Primary Objective: To determine the feasibility of patients completing stereotactic body radiation therapy and at least one (1) cycle of Pembrolizumab.

Secondary Objectives:

  • Evaluate the radiographic response after decompressive stereotactic body radiation therapy and Pembrolizumab by calculating the improvement in thecal sac patency (see 5.2.1).
  • Evaluate accrual rate,
  • Evaluate pain relief.
  • Evaluate quality of life.
  • Evaluate cumulative incidence of adverse events.
  • Evaluate potential correlative blood biomarkers.

Details
Condition Epidural Spinal Tumors, Cancer
Treatment Pembrolizumab, stereotactic body radiation therapy, Blood draws
Clinical Study IdentifierNCT05204290
SponsorWake Forest University Health Sciences
Last Modified on30 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Pathologic diagnosis of cancer, confirmed by review of pathology report
Epidural disease seen on MRI at 1 vertebral level or 2 contiguous vertebral level
Synchronous and metachronous sites of disease allowed
Patient with expected life span of ≥ 3 months
Deemed eligible for stereotactic body radiation therapy and pembrolizumab after multi-disciplinary review. The multi-disciplinary review will be conducted virtually via our Spinal Oncology Group (SPOG) Wake Forest e-mail listserv. Members of the distribution list include neurosurgeons, orthopedic surgeons, interventional radiologists, radiologists, and radiation oncologists. This group meets monthly via Webex and in the interim, cases are routinely reviewed using encrypted emails via the listserv. Because we will not be able to wait for a month meeting to enroll patients on study, we anticipate needing to review these patients via the listserv. The electronic review will serve as documentation of multi-disciplinary review
Patients currently being treated with pembrolizumab or anticipated to receive at least one dose of pembrolizumab within six weeks after finishing stereotactic body radiation therapy
Patients who have received prior immunotherapy are allowed
Age equal or greater than 18
Ability to understand and the willingness to sign an IRB-approved informed consent document (either directly or via a legally authorized representative)

Exclusion Criteria

Prior radiation therapy or surgery to index lesion
Patients with lymphoma, multiple myeloma, germinomas, seminomas, Wilm's tumors, and Ewing's sarcomas will be excluded
Muscle strength of ≤ 3 out of 5 on neurologic exam that correlates with level of the involved spinal cord
Retropulsed compression fracture
Patients with a contraindication to pembrolizumab
Patients may not be receiving any other investigational agents
Patients with symptomatic, brain metastases, as determined by the study PI, that could confound the neurologic exam, should be excluded
Uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
Pregnant women are excluded from this study because both radiation and pembrolizumab can be harmful to the developing fetus. Because there is an unknown but potential risk for adverse events, pregnant women are not allowed to participate in this study, in nursing infants secondary to treatment of the mother with pembrolizumab, breastfeeding should be discontinued
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