The Home Blood Pressure (BP) Trial (Home-BP)

  • STATUS
    Recruiting
  • End date
    Apr 30, 2026
  • participants needed
    200
  • sponsor
    University of Washington
Updated on 15 June 2022

Summary

The main study will be a two arm 10-month, cross-over randomized controlled trial of 200 participants treated with end-stage-kidney-disease treated with in-center hemodialysis in the Seattle and San Francisco area comparing a strategy of targeting home vs. pre-dialysis systolic blood pressure <140 mmHg to reduce rates of intradialytic hypotension. The target systolic blood pressure of <140 mmHg in both treatment groups will be achieved using an algorithm of dry weight adjustment and anti-hypertensive medication adjustment.

Description

The main study be a two arm 10-month, cross-over randomized controlled trial of 200 participants treated with in-center hemodialysis in the Seattle and San Francisco area comparing a strategy of targeting home vs. pre-dialysis systolic blood pressure <140 mmHg in reducing rates of intradialytic hypotension. The target systolic blood pressure of 100-140 mmHg will be achieved using an algorithm of volume management and anti-hypertensive medication adjustment every two weeks. Home blood pressure measures will be recorded throughout via a mobile health blood pressure monitor over the 10-month study.

Details
Condition End Stage Renal Disease on Dialysis
Treatment Anti-Hypertensive medications, Dry weight target adjustment
Clinical Study IdentifierNCT05159999
SponsorUniversity of Washington
Last Modified on15 June 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Aged 18 years or older
Undergoing in-center, thrice weekly hemodialysis for treatment of end stage renal disease (ESRD)
Greater than 3 months since initiation of dialysis
No anticipated change to peritoneal dialysis or kidney transplant within 10 months
Life expectancy greater than 10 months
Hypertension (defined as mean pre-dialysis SBP > 140 mmHg over prior 2 weeks or taking BP medications)
Able to obtain/measure a brachial blood pressure at dialysis and at home (e.g., no left ventricular assist device, blood pressure not been taken routinely in lower extremity at dialysis unit)
No condition that the primary nephrologist or PIs feel precludes participation

Exclusion Criteria

Incarcerated or institutionalized (prohibits home blood pressure measurement)
Participating in another intervention study that may affect blood pressure
Pregnant or anticipated pregnancy or breastfeeding (as this will require increase to more than three times a week dialysis and/or preclude use of some classes of blood pressure medications)
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