Study on Opioid-free Anesthesia Protocol With S-ketamine and Propofol

  • days left to enroll
  • participants needed
  • sponsor
    The First Affiliated Hospital with Nanjing Medical University
Updated on 4 October 2022


The purpose of this study was to observe the effects of opioid-free anesthesia with S-ketamine on postoperative analgesia and perioperative hemodynamics in short surgical operations, and to explore the effects of S-ketamine on postoperative awakening time and extubation time, nausea and vomiting, hypoxemia, and delirium.

Condition Opioid Use, Unspecified, S-ketamine
Treatment Fentanyl, Sufentanil, S-ketamine
Clinical Study IdentifierNCT05242081
SponsorThe First Affiliated Hospital with Nanjing Medical University
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Aged from 18 years to 65 years
American society of anesthesiologists physical status classification I-II
Patients scheduled for elective laparoscopic cholecystectomy
Willing to sign informed consent

Exclusion Criteria

Allergic to narcotic drugs
Surgical history within the past 1 month
patients with neurological diseases or mental disorders
Unable to understand numerical rating Scale (NRS)
patients with untreated or poorly controlled hypertension (arterial hypertension, resting systolic/diastolic blood pressure over 180/100mmHg)
patients with untreated or undertreated hyperthyroidism
Patients with unstable angina pectoris or myocardial infarction in the past 6 months
When intraocular pressure is high (glaucoma) and penetrating ocular trauma, intraocular pressure cannot rise
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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