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Known allergy or sensitivity to any study medication or its components, any component of the delivery vehicle, procedure-related materials, or diagnostic agents used during the study (eg, topical anesthetic, dilating drops, fluorescein, povidone-iodine)
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Concurrent or anticipated enrollment in an investigational drug or device study or participation in such a study within 2 months prior to the Baseline visit through the final study visit
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History of intracameral implant in the study eye (eg, Bimatoprost SR, OTX-TIC, ENV515 Travoprost XR)
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History of laser trabeculoplasty within 6 months prior to screening in the study eye
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History or evidence of clinically relevant, substantial ocular trauma (eg, a traumatic cataract, traumatic angle recession, etc.) in the study eye
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History or evidence of complicated cataract/lens surgery: eg, surgery resulting in complicated lens placement (such a anterior chamber intraocular lens implant [IOL], sulcus IOL, aphakia, etc.) or intraoperative complications (such as a posterior capsular tear [with or without vitreous loss], substantial iris trauma, etc.)
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Intraocular surgery (including cataract surgery) in the study eye within the 4 months prior to treatment administration
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Any history of corneal graft, including partial grafts (eg, Descemet's Stripping Endothelial Keratoplasty [DSEK], Descemet's Membrane Endothelial Keratoplasty [DMEK]); or incisional refractive surgery (eg, radial keratotomy), other than astigmatic keratotomy or limbal relaxing incisions in the study eye
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History of herpetic ocular diseases in either eye (including herpes simplex virus and varicella zoster virus)
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Anticipated need for any incisional or laser ocular surgery in either eye during the study
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History of anatomically narrow angle resulting in evidence of angle changes or any history or closed angle glaucoma in the study eye
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History or evidence of a peripheral iridotomy/iridectomy in the inferior iris in the study eye
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Any history of trabeculectomy or other types of incisional glaucoma surgery, including a glaucoma seton or aqueous bypass stents in either eye, or minimally invasive glaucoma surgery (MIGS) type trabecular meshwork surgeries in the study eye
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Anticipated use of corticosteroids in either eye except for permitted interventions or systemically during the study, or historical use prior to Baseline within
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years: intraocular fluocinolone acetonide
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months: intraocular corticosteroid(s) other than fluocinolone; any injectable periocular or sub-Tenon's/subconjunctival corticosteroid
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months: systemic (eg, oral, intramuscular, intravenous) or topical ocular corticosteroids
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weeks: dermal corticosteroids applied to skin of the eyelid(s), around the eye, or adnexa
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Anticipated use of other topical ocular medications in either eye except for permitted interventions
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The anticipated wearing of contact lenses in the study eye (Cohort 1) and both eyes (Cohort 2) during the study that deviates from the following (contact lens wear is allowed during the study, but is to be temporarily discontinued before study visits, and before and after an Administration Day according to the following)
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Use of soft lenses should be discontinued at least 3 days prior to Baseline, and use of rigid gas permeable or hard contact lenses should be discontinued at least 1 week prior to Baseline
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Use of soft lenses should be discontinued at least 3 days and use of rigid gas permeable or hard contact lenses should be discontinued at least 1 week prior to a scheduled study visit or Administration Day visit
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Use of contact lenses of any kind should be discontinued for 1 week following any AGN-193408 SR administration
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Central corneal thickness of < 480 or > 620 micrometers in both eyes
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Visual field loss in the study eye that, in the opinion of the investigator, is functionally significant (eg, split fixation, field defect within the central 10 degrees that is visually significant or likely to cause central visual impairment upon progression) or shows evidence of progressive visual field loss within the year prior to Baseline
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Evidence of macular edema in either eye during screening or in participant's medical history
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