The Impact of Oxidative Stress on Erythrocyte Biology (RBC Survival)

  • STATUS
    Recruiting
  • End date
    Oct 10, 2024
  • participants needed
    16
  • sponsor
    University of North Carolina, Chapel Hill
Updated on 10 March 2022

Summary

This study will address if red blood cells transfused to a sickle cell patient from a donor with a glucose-6-phosphate-dehydrogenase (G6PD) enzyme deficiency have a different lifespan as measured by the percentage of red blood cells that survive post-transfusion compared to red blood cells transfused to a sickle cell patient from a donor without a G6PD enzyme deficiency.

Description

This prospective, phase II, crossover, single-blind, randomized transfusion order study will address if red blood cells from donors with a G6PD enzyme deficiency have a different lifespan once transfused into a patient with sickle cell disease than red blood cells from an otherwise normal donor. Results of this critical study will guide future research and donor testing policies to ensure that patients receive the most appropriate units of blood for their condition. Each patient randomized to the study will receive 2 blood transfusions, one from a G6PD deficient donor and one from an otherwise normal donor. Half the patients (8) will receive G6PD deficient blood first while the other half (8) will receive non-G6PD deficient blood first. Patients will have a wash-out period of at least 4 months before receiving the opposite type of blood transfusion. The blood transfusion order will be randomized. There is currently no standard of testing in place to screen blood donations for G6PD enzyme deficiency. It is believed that up to 10% of the antigen-matched donors for patients with sickle cell disease are G6PD deficient, and the lifespan is unknown in the sickle cell population.

Details
Condition Sickle Cell Disease Without Crisis
Treatment G6PD Deficient Red Blood Cell Transfusion, Non-G6PD deficient Red Blood Cell Transfusion
Clinical Study IdentifierNCT04028700
SponsorUniversity of North Carolina, Chapel Hill
Last Modified on10 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 18-60 years
HbSS/HbSβ0-thalassemia
Steady state (no pain or baseline pain and ≥1 month from any hospital admission)
Receiving chronic transfusions (i.e regular transfusion every 4-8 weeks)

Exclusion Criteria

History of transfusion reactions not adequately managed by antihistamines
≥2 alloantibodies or warm autoantibodies
Known G6PD deficiency
Hepato- or splenomegaly
Participation in another therapeutic trial
Pregnant or nursing
HIV positive
At investigator discretion for uncontrolled inter-current illness or social situation limiting compliance with study requirements
Inability to speak and/or read English
Clear my responses

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