Genetic, Microenvironmental, and Immunological Factors in Unresectable Pancreatic Ductal Adenocarcinoma
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- STATUS
- Recruiting
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- End date
- Jul 10, 2026
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- participants needed
- 250
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- sponsor
- Catholic University of the Sacred Heart
Summary
Pancreatic ductal adenocarcinoma (PDAC) complexity, where genetic, stromal, and immunological factors all interact with each other, is responsible for the overall poor response of PDAC to chemotherapeutic agents, making this a lethal disease. The investigators hypothesize that: (i) dissection of genetic, stromal, and immunological factors on endoscopic ultrasound fine needle biopsy (EUS-FNB) tissue samples from unresectable PDAC patients' will allow to determine prognostic factors in this patient population; (ii) treatment response and acquisition of tumor chemotherapy resistance could be related to genetic heterogeneity between the primary and metastatic sites and alteration of the molecular profile under drug' selection pressure.
Details
| Condition | Pancreas Cancer |
|---|---|
| Clinical Study Identifier | NCT05248750 |
| Sponsor | Catholic University of the Sacred Heart |
| Last Modified on | 26 April 2022 |
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