The Effect of Mechanical Ventilation on the Occurrence of Myocardial Ischemia: a Pilot Study (VENTMICS)

  • STATUS
    Recruiting
  • days left to enroll
    21
  • participants needed
    10
  • sponsor
    Jessa Hospital
Updated on 22 March 2022
ischemia

Summary

The goal of the proposed pilot study is to determine which method can detect myocardial ischemia at the predefined timepoints during endo-CABG. Additionally, the investigators want to examine the influence of mechanical ventilation on the occurrence of myocardial ischemia in patients undergoing endo-CABG.

Description

CABG is the most effective therapy for patients suffering from coronary artery disease, a condition which annually affects 126 million people worldwide. During this surgery, cardiopulmonary bypass (CPB) takes over the function of the heart and lungs. As a result of the emergence of minimally invasive cardiac surgery (MICS) (e.g. endoscopic-CABG), peripheral CPB with femoral arterial cannulation became the most commonly utilized strategy. However, the use of retrograde arterial perfusion is not without risk. It may result in the upper body and coronary arteries being perfused with deoxygenated blood. The hypoxemia will induce myocardial ischemia and this can harm the cardiac myocytes. A solution for this inconvenience is still lacking. Literature reports that establishing adequate ventilation support should help overcome this phenomenon. However, this approach has not yet been investigated in a clinical trial. In general, this phenomenon is not well recognized in the typical surgical setting, and limited research has been done.

The goal of the proposed pilot study is to determine which method can detect myocardial ischemia at the predefined timepoints during endo-CABG. Additionally, the investigators want to examine the influence of mechanical ventilation on the occurrence of myocardial ischemia in patients undergoing endo-CABG.

Details
Condition Myocardial Ischemia, Hypoxia
Treatment Continued ventilation, Discontinued ventilation
Clinical Study IdentifierNCT05109715
SponsorJessa Hospital
Last Modified on22 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Age > 18 years old
Patients undergoing their first elective endo-CABG procedure
Patients capable of signing the informed consent
Patients able to speak Dutch or French

Exclusion Criteria

Ongoing participation in another trial
Ejection fraction < 50%
Lung diseases (COPD, asthma)
Use of corticosteroids
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